[acb-diabetics] many articles

[Patricia LaFrance-Wolf]

1.  MW   Corneal Confocal Microscopy Shows Presence, Severity of Diabetic
Neuropathy (Reuters Health) May 20 - Corneal confocal microscopy accurately
and

noninvasively diagnoses the presence and severity of diabetic neuropathy.
Although it's not quite ready for widespread adoption, senior author
believes

"this technique has huge potential, as we have now repeatedly shown that it
can detect early nerve damage and stratify the severity in diabetic
neuropathy."

[101 diabetics & 17 nondiabetic subjects] Vibration perception threshold
increased significantly with severity of neuropathy.Corneal sensitivity was
lower

in DM patients compared to healthy volunteers, but the difference was
significant only in patients with severe neuropathy. Corneal nerve fiber
density,

branch density, and length were significantly and progressively reduced in
the diabetics (including those without neuropathy). "This is a novel but
clinically

applicable test of neuropathy which we would see sitting alongside retinal
screening," Diabetes Care 2010.

 

2.%%ADA Low Muscle Mass Ups Diabetes Risk 6/2/10 Researchers at  UCLA
suggest that sarcopenia, defined as low skeletal muscle mass and strength,
often

found in older or obese individuals, may increase the risk of T2DM. [14,528
people] Sarcopenia was associated with insulin resistance in both obese and

non-obese individuals.  The condition was also associated with high
blood-sugar levels in obese people but not in thinner individuals.  These
associations

were greater in people age 60 years and under.  Based on the results, the
researchers suggest that dieting may not be enough, but that good muscle
mass

and strength should be a focus in preventing diabetes.  

 

3.%% MNTD Two Promising Proteins For Preventing Diabetes 5/25/10 Two human
proteins that evolutionary processes have conserved from ancient
single-celled

organisms appear to provide new targets of opportunity for scientists hoping
to thwart the development of DM. 

In experiments using diabetes-prone mice, blocking the actions of the
proteins significantly reduced the development of DM in the mice.  Diabetes
can occur

when the body is unable to produce enough insulin, or when it loses its
ability to respond properly to the production of insulin, a hormone the body
uses

to convert food into

energy. No matter the cause, research suggests that inflammatory processes
contribute to the development of diabetes. One of the proteins, eIF5A, is
believed

to be involved with inflammation processes. The team looked at eIF5A because
its corresponding

gene sits near other inflammation-related genes in both the mouse and human
genomes. The team leader said "Because it sat in a hotbed of inflammatory
genes, 

we thought eIF5A might also have role in the progression of diabetes," But
eIF5A doesn't act on its own. Instead, another protein, an enzyme called
DHS,

is necessary to activate eIF5A .. then inhibiting DHS should block eIF5A,"
They  used two different approaches to block the activity of eIF5A. Both
gave

similar results - that the development of DM can be blocked in a mouse - but
the DHS approach seems to offer a more promising route

to possible treatments.

 

4.%% MNTD  Link Between Viral Infection & Juvenile Diabetes (T1)

5/25/10  Researchers have found a significant association between
enteroviral infection and diagnosis of T1DM in children. In T1 the patient's
own immune

system is somehow activated to slowly destroy insulin-producing beta cells
in the pancreas .Approximately 13,000 young people are diagnosed in the US
each

year. T1 develops in individuals who are genetically susceptible.. exposure
to some yet unknown triggering environmental factor or factors may be
required. 

[112 children at the time of diagnosis] Low-level enteroviral infectivity
and genome fragments were detected in 83% of T1 patient  compared to only 7%

of healthy controls. "These data do not provide a causal relationship
between enterovirus infections and DM,  However, the high prevalence of
enteroviral

genome sequences in newly diagnosed T1 s cases indicate that different
enterovirus types represent a significant biomarker of early stage juvenile
diabetes."

 

5.%% MW Dialysis Linked to Foot Ulceration in Diabetic Patients

6/1/10 — Dialysis treatment is independently associated with foot ulceration
in patients with DM and stage IV or V chronic kidney disease (CKD).[ 326 DM

pts with CKD] Patients were evaluated for DM

 peripheral neuropathy (DPN), peripheral arterial disease (PAD), prior

foot ulceration and amputation, and foot self-care. "Dialysis treatment was
independently associated with foot ulceration," the study

authors write. "Guidelines should highlight dialysis as an important risk
factor for foot ulceration requiring intensive foot care."

 

6.%% Ophthalmology 117,6 June 2010 OphSource  A Prospective Randomized Trial
of Intravitreal Bevacizumab or Laser Therapy in the Management of Diabetic

Macular Edema (BOLT Study):Purpose

To report the findings at 1 year of a study comparing repeated intravitreal
bevacizumab [avastin] (ivB) and modified Early Treatment of Diabetic
Retinopathy

Study (ETDRS) macular laser therapy (MLT) in patients with persistent
clinically significant diabetic macular

edema (CSME). [80 eyes of 80 pts] Conclusions The study provides evidence to
support the use of bevacizumab in patients with center-involving CSME
without

advanced macular ischemia.

 

7.%% Ophth 117,6 June 2010 Vitrectomy Outcomes in Eyes with Diabetic Macular
Edema and Vitreomacular Traction [87 eyes]

 Conclusions After vitrectomy performed for DME and vitreomacular traction,
retinal thickening was reduced in most eyes. Between 28% and 49% of eyes
with

characteristics similar to those included in this study are likely to have
improvement of visual acuity, whereas between 13% and 31% are likely to have

worsening. The operative complication rate is low and similar to what has
been reported for this procedure. These data provide estimates of surgical
outcomes

and serve as a reference for future studies that might consider vitrectomy
for DME in eyes with at least moderate vision loss

and vitreomacular traction.

 

8.%%Ophth 117,6 June 2010 Automated Early Detection of Diabetic Retinopathy
Purpose - To compare the performance of automated diabetic retinopathy (DR)

detection, using the algorithm that won the 2009 Retinopathy Online
Challenge Competition in 2009, the Challenge2009, against that of the one
currently

used in EyeCheck, a large computer-aided early DR detection project. [16670
pts] Conclusions -  Diabetic retinopathy detection algorithms seem to be
maturing,

and further improvements in detection performance cannot be differentiated
from best clinical practices, because the performance of competitive
algorithm

development now has reached the human intrareader variability limit.
Additional validation studies on larger, well-defined, but more diverse
populations

of patients with DM are needed urgently, anticipating cost-effective early
detection of DR in millions of people with DM to triage those patients who
need

further care at a time when they have early rather than advanced DR.

 

9.%%Ophth 117,6 June 2010 Prevalence of Refractive Errors and Associated
Risk Factors in Subjects with T2DM  SN-DREAMS, Report 18 [1080 subjects with
DM]

Conclusions - The present population- based study from urban India noted a
high prevalence of refractive

errors (60%) among diabetic subjects >40 years old; the prevalence of
astigmatism (47%) was higher than hyperopia (40%) or myopia (20%).

 

10.%% MW"Puzzling" Lancet Paper Posits Low-Dose Rosiglitazone/ Metformin for
Diabetes Prevention 6/3/10  With just over a month to go before
rosiglitazone

(Avandia) makes its reappearance in front of an FDA review panel, a
surprising study---suggests that half-dose rosiglitazone combined with
half-dose metformin 

may help prevent progression to DM. Experts not involved with the study were
quick to point out to heartwire that the new study does nothing to alleviate

concerns about the drug. Lead author on this new paper stressed that the
main point of the research was that reduced doses of available drugs--not
necessarily

rosiglitazone--may help reduce progression to diabetes.  [207 pts;Fup 4 yrs]
occurrence of incident DM  was significantly lower in patients assigned to

the combination drug,  One of the most outspoken critics of rosiglitazone,
Dr Steven Nissen, said  ..Despite the authors' claims, there is no evidence

whatsoever that lower doses of rosiglitazone are 'safe.' Any suggestion that
serious CV toxicity can be avoided by using a small dose represents pure
speculation

at best."...

 

11.%% MW Group Medical Clinics Improve BP, But Not Glycemic Control, in
Diabetics 6/2/10 The use of group medical clinics (GMCs)--where 7or 8
patients

are seen together with a doctor, pharmacist, and nurse educator--resulted in
clinically meaningful

improvements in blood pressure, but not in glycemic control, compared with
usual care in a study in diabetics conducted at two VA medical centers [239

pts with poorly controlled DM] The groups met for half a day every 2 months
and each group met with the same care team at each visit. They liked the
element

of talking to other patients and getting their advice.. The veterans
attending the GMC had better BP control than those who received usual care
at 6 months,

and this difference was sustained at one year. But there was no significant
difference between the groups in terms of improvement in HbA1c.

 

12.%% MW Thiazolidinediones and Sulfonylureas Most Effective in Lowering
HbA1C 6/2/10 — Oral antidiabetic drugs (OADs) decrease glycosylated
hemoglobin

(A1C) levels by approximately 0.5% to 1.25%. The maximal effect is achieved
by 3 to 6 months, and thiazolidinediones and sulfonylureas show the greatest

efficacy, according to the findings of a systematic review and
meta-analysis.

The team searched several databases for randomized, placebo- controlled
studies [26,367 study participants] The authors concluded that the benefit
of initiating

an OAD agent is most apparent within the first 4 to 6 months, with A1C
levels unlikely to decrease more than 1.5% on average.

.

13.%% ADA Total fat mass and central adiposity increase the risk of
cognitive impairment in older subjects with diabetes 6/2/10

The association between adiposity parameters and body fat distribution with
cognitive impairment was evaluated in a longitudinal study enrolling (253 DM

pts & 440 subjects with normal glucose tolerance [NGT])aged 65-85 yr;Fup
2yr.  the researchers observed that waist-hip ratio and waist circumference
significantly

correlated with MMSE (Mini Mental State Examination) and a composite score
of executive and attention functioning. In addition, total fat mass  and
greater

central adiposity increased by 2- and 1.5-fold, respectively, the risk of
global cognitive decline in diabetics.., no significant impact was observed
in

NGT subjects. PLoS One 2010, 5(4

 

14.%% ADA  Study Links Air Pollution With Diabetes in Women 6/2/10
Traffic-related air pollution has been shown to increase T2 risk in

a German study of 1,775 women.  The team compared those who lived in highly
polluted industrial areas with those who lived in rural, less-polluted
regions. 

Components of traffic pollution, especially nitrogen dioxide and soot in
fine particulate matter, were significantly associated with a higher T2.
Residence

within 100 meters [328 ft] of busy roads was also found to increase the
diabetes risk.  The team

reports their findings in Environmental Health Perspectives.

 

15.%% JH Promising Therapies for Macular Edema 6/4/10 Laser therapy, also
called laser photocoagulation, is more effective and produces fewer side
effects

than corticosteroids injected into the eye for the treatment of diabetic
macular edema [DME] according to a large, 2-year multicenter study. Swelling
around

the macula (macular edema) caused by the leakage and accumulation of fluid
can occur in people with DM. The swelling alters the position of the retina

and causes blurred vision. Loss of vision is more pronounced when the center
of the macula is affected. Photocoagulation uses lasers to help close
leaking

microaneurysms (weak spots that bulge outward from the blood vessels),
fostering the regression of new blood vessels. Laser helps to halt or slow
vision

loss in most people if performed before too much damage has occurred. [693
people with DME to undergo laser treatment or to receive a 1- or 4-mg
injection

of triamcinolone (a corticosteroid) into the eye, each repeated at 4month
intervals, as necessary. At the first 4-month check, vision was sharpest in

those who had received a 4-mg injection of triamcinolone. At one year,
vision was about the same in all 3 groups. But at 2 years, vision was
significantly

better in the laser treatment group. Of those who received laser 19% had
substantial vision loss compared with 28% in the corticosteroid treated
groups.

Cataract surgery was required in 13% of eyes in the laser group compared
with 23% in those who received 1 mg of triamcinolone and 51% in those who
received

4 mg. Eye pressure increased by a significant amount in 4% of the laser
group compared with 16% & 33% in the corticosteroid groups, respectively.
Researchers

are now studying combination therapy, since triamcinolone had better initial
results and laser treatment was more effective over two years.

 

16.%% MW New Statement Urges Caution for Primary-Prevention Aspirin in
Diabetics 6/3/10 The joint statement from ADA, Am Heart Assoc, and Am
College of

Cardiology recommends that low-dose aspirin is "reasonable" in diabetics
with no history of vascular disease but who are at an increased 10-year risk

of CV events. The organizations state that only men older than 50 and women
older than 60 who have one or more additional major risk factors should be

treated with aspirin for primary prevention of CV events. "The guidelines
are more conservative, and this is based on some of the newer studies that
have

come out," a member of the writing committee said. "The previous
recommendations had been that pretty much anybody with diabetes over the age
of 40 should

be on aspirin." The group recommends low-dose aspirin, 75 mg/d to 162 mg/d,
for adults with DM and no history of cardiovascular disease but who are at

an increased risk based on age and at least one additional CVD risk factor,
such as smoking, dyslipidemia, hypertension, family history of disease, and

albuminuria. Aspirin is not recommended for high-risk diabetic patients who
are also at risk for bleeding and is not recommended for individuals at low

risk of CV events. With no single study providing definitive results, the
ommittee attempted to reconcile the findings by examining existing
meta-analyses,

such as the one performed by the Oxford Antithrombotic Treatment Trialists'
(ATT) [4000 DM pts]  Heartwire © 2010

 

17.%% MW High-Dose B Vitamin Therapy May Not Be Helpful in Diabetic
Nephropathy 6/3/10  Compared with placebo, high doses of B vitamins were
actually associated

with a greater decrease in glomerular filtration rate (GFR) and an increase
in vascular events.

"Hyperhomocysteinemia is frequently observed in patients with diabetic
nephropathy," writes a team member. "B-vitamin therapy has been shown to
lower the

plasma concentration of homocysteine." [238 patients with T1 or T2 & DM
nephropathy] Participants were randomly assigned to receive a single tablet
daily

of B vitamins

containing folic acid (2.5 mg/day), vitamin B6 (25 mg/day), and vitamin B12
(1 mg/day), or matching placebo. "There is an expected decline in
homocysteine

levels in the treatment group compared to the placebo group, but despite
this the active treatment turns out to have detrimental effects on both
renal

function and vascular complications." "Clearly, the results call for caution
in using high dose B vitamins (pharmacological doses) in high risk patients

like DM patients with diabetic nephropathy, On the other hand it is
important to stress that the results do not imply that multivitamins
containing usual

low doses of B vitamins are harmful."

 

18.%% Heartwire  More Evidence Against Concept of "Metabolic Syndrome"
5/21/10  Patients with metabolic syndrome are no more at

risk of future MI than those with diabetes or hypertension alone, a new
study suggests. "Our study examined whether we need to look at metabolic
syndrome

as a distinct entity or whether we should instead be focusing on the
individual risk factors, and we found that the individual risk-factor
approach is

probably best.  the researchers explain that the common clustering of
metabolic abnormalities,

including abdominal obesity, elevated glucose, abnormal lipids, and elevated
BP is often referred to as the metabolic syndrome.[12, 297 cases;14,606
controls]

Results showed that metabolic syndrome was associated with a 2-3times
increased risk of MI, but the same risk was conferred by having either
hypertension

or DM alone.

 

19.%% Am J Oph 149,6 June 2010 Nocturnal Intermittent Serious Hypoxia &
Reoxygenation in Proliferative Diabetic Retinopathy (PDR) [68
non-PDR;151(PDR)

subjects] Pulse oximetry was conducted overnight and mean oxygen saturation
by pulse oximeter (SpO2; %),. Conclusions - This study indicated that PDR
cases

had episodes of nocturnal intermittent hypoxia and reoxygenation as a result
of sleep-disordered breathing and that low-value lowest SpO2  were the risk

factors for PDR development.

 

20.%% Am J Oph 149,6 June 2010 Barely Visible 10-Millisecond Pascal Laser
Photocoagulation for Diabetic Macular Edema: (DME) Observations of Clinical
Effect

and Burn Localization  Conclusions

The technique of lower-fluence barely visible 10-millisecond laser may
reduce retinal edema within affected sectors and effectively treat DME with
minimization

of scar formation.

 

21.%% MW 5/28/2010 — Increases in waist circumference and weight may predict
incident diabetes. "Individuals with impaired fasting glucose (IFG) are at

high risk for T2," the research team writes. [979 subjects;Fup 9yr] After
adjustment for risk factors at baseline,

increases in both waist circumference and weight were significantly
associated with DM incidence."In IFG individuals, it is important to monitor
and prevent

increases in waist circumference. "We speculate

that an increase in waist circumference may induce further alterations in
insulin secretion beyond that inherent in a worsening insulin resistance.
Potential

mechanisms may involve ß-cell lipotoxicity through enhanced free fatty acid
release from adipose tissue."

 

22.%% MW Urinary Incontinence in Diabetic Women Is Often Neglected 6/3/10
Physicians need to pay closer attention to the possibility of urinary
incontinence

(UI) in their female diabetic patients, because 35% of this population
reports at least weekly episodes, a group said at the Am Urological Assoc
Annual

Scientific Meeting. The study found  that DM women with weekly UI episodes
seek treatment less often than nondiabetic women with UI and have less
understanding

of UI and more UI-related depression. "The good news is that effective
treatments are available for UI. It's unfortunate that diabetic women are
often

denied such treatments simply because we don't know they suffer from
UI."[488 pts with DM;1784 nondiabetic women].

 

23.%% Diabetes Mellitus and the Haptoglobin 2-2 Genotype 6/1/10; )  Aims:
Individuals with both (DM) and the Haptoglobin (Hp) 2-2 genotype are at
increased

risk of cardiovascular [CV] disease. As the antioxidant function of the Hp
2-2 protein is impaired, we sought to [test whether] antioxidant vitamin E
supplementation

would provide [this group] CV protection There was a significant reduction
in MI in Hp 2-2 individuals with vit E, There was no benefit of vit E on
myocardial

infarction in non-Hp 2-2 individuals. Discussion In meta-analysis of two
independent placebo controlled clinical trials Hp 2-2 DM individuals
(representing

approximately 36% of all diabetics)  derived significant CV protection from
vitamin E supplementation, with an overall reduction of over 40% in the
combined

end point of stroke, MI and CVD death. Conclusion Hp typing represents a
once in a lifetime test that identifies those DM individuals at
exceptionally

high risk of CVD. The Hp type may be used to more effectively focus the
attention of the clinician and the utilization of healthcare resources on
those

DM individuals for whom more aggressive risk factor modification is most
needed. The Hp genotype also appears to identify a very large subgroup of DM
individuals

who may receive marked clinical benefit from an extremely inexpensive
therapy. Pharmacogenomics. 2010;11(5): © 2010 Future Medicine Ltd.

 

24.%% MNTD Team Discovers Important New Player In Diabetes Onset 6/8/10  If
you think of DM onset like an elaborate molecular drama, then a research
team

has unmasked a previously unknown cellular player, which is critical to
proper insulin secretion. "Defective insulin secretion is a hallmark of both
T1

& 2 ," said the team leader 

Working in mouse models, the team discovered that the ABCG1  protein is
essential for the beta cells of the pancreas to produce sufficient amounts
of insulin.. 

previous findings show that T2 pts  have lower levels of ABCG1 than
non-diabetics. The team also showed that proper expression of the ABCG1
protein in

beta cells could be restored in the mice by treatment with some existing
antidiabetic drugs. ""Our research points to the need to investigate this
possibility

further as well as to explore the potential development of new therapies
that boost ABCG1 protein levels and insulin secretion,"  "We found that
ABCG1

actually sits inside the beta cell and that it's really important for
delivering cholesterol  to the insulin granule membranes. Without
cholesterol the

insulin granules do not develop or function properly and, release
significantly less insulin.  The team believes that boosting the levels of
ABCG1 in DM

patients may benefit sufferers in 2 ways by aiding in reducing arterial
plaque  and in improving insulin production. . Editorial comment "This
mechanism

may be very helpful for people with T2 but also T1 because it may extend the
period of time before all insulin-producing potential is gone,"  ( La Jolla

Institute)  

 

25.%%JH "Bloodless" Glucose Testing: Where We Stand 6/10/10

Self-testing of blood glucose with a blood glucose meter is one of the
central elements of caring for your diabetes. Of course, pricking

your finger with a needle several times a day is not fun . Recently a reader
asked us: Is there a way to check your blood glucose level that doesn't
require

a needle prick? Here’s what we know 
 Don't toss out your lancets and test
strips just yet. A number of medical-device

makers have tried to create methods to measure blood glucose that do not
require puncturing the skin with a sharp object to extract a drop of blood.
Unfortunately,

no one has yet figured out the secret to accurate "bloodless" glucose
testing. ..the Dream Beam  was supposed to measure blood sugar by passing
light through

your finger. However, the device did not produce accurate readings and, like
many other attempts, failed as an alternative to finger-prick testing.  The

only noninvasive blood glucose monitor ever to gain approval from FDA
GlucoWatch Biographer, caused many users to develop skin rashes and was
taken off

the market in 2007. Nonetheless, several companies are trying to develop
monitors that use infrared light, electromagnetic waves, and other
technologies

to measure glucose levels. Bottom Line: If you're bothered by finger pricks,
don't stop testing; instead, try less painful methods, such as using lancets

that don't puncture the skin so deeply. And look also to the real advance
over the past few years: availability of continuous glucose monitoring
(CGM).

 

26. %%MNTDPhase 3 Study Showed Macugen(R) Improved Vision Over Standard Of
Care In Patients With Diabetic Macular Edema

6/8/10  Macugen (pegaptanib) significantly improved vision in patients with
diabetic macular edema (DME),37 % of patients treated with the drug  gained

two lines, or 10 letters, on the ETDRS eye chart at 54 weeks, compared to 20
% of patients who received a (placebo-like) procedure. All patients enrolled

in the study were eligible to receive laser therapy, the current standard of
care for DME, beginning at week 18 of the study at the physician's
discretion.

[260 patients] 

 

27.%% Eye (2010) 24, Association of intraocular pressure with the metabolic
syndrome and novel cardiometabolic risk factors [1112 subjects]  Conclusion

- Met. syndrome and other insulin resistance- related features, increased
left ventricular mass, and proteinuria, are strongly associated with IOP.

 

28.%%MW Restrictive Lung Disease Linked to Incident Type 2 Diabetes 6/10/10
— Restrictive lung function impairment is associated with incident T2DM  and

fatal coronary heart disease (CHD)[4434 men aged 40 - 59 years with no
history of CHD, stroke or DM ; Fup 20yrs] ] "Restrictive rather than
obstructive

impairment of lung function is associated with incident T2 (and fatal CHD)
with both associations partially explained by traditional and metabolic risk

factors and inflammation," the study authors write.

.

29.%% 6/10/10 NIH News: NEI Hosts Translational Research and Vision
Symposium June 24-25  The National Eye Institute (NEI), part of the NIH, is
bringing

together premier researchers who translate molecular and genetic approaches
from the laboratory to visual system diseases in the clinic. This event will

feature discussions about cutting-edge treatment strategies as well as the
impact of the human genome sequencing on diagnosis and treatment of eye
diseases.

Speakers will include:-- Ben Barres, M.D., Ph.D., Stanford U-- Edward S.
Boyden, Ph.D., MIT-- Emily Y. Chew, M.D., NEI -- Dennis O. Clegg, Ph.D.,
UCSB--

Mark S. Humayun, M.D., Ph.D., USC-- Samuel G. Jacobson, M.D., Ph.D., U of
Pennsylvania  -- Jay Neitz, Ph.D., U Washington -- James M. Wilson, M.D.,
Ph.D.,

U of Penn

 

30.%% Substituting Whole Grains for White Rice May Lower Risk for T2DM
6/14/10 — Substituting brown rice or other whole grains for white rice is
associated

with a lower risk for T2.[39765 men;157,463 women] The team estimated that
replacing 50 g [1/4 cup] per day of uncooked white rice (one-third serving
per

day) with the equivalent amount of brown rice was associated with a 16%
lower risk for T2. "These data support the recommendation that most
carbohydrate

intake should come from whole grains rather than refined grains to help
prevent T2s." Arch Intern Med. 2010;170:

 

31.%% Exenatide, Lifestyle Changes Lead to Weight Loss in Obese Diabetics
(Reuters Health) Jun 08 - [194pts;24 wk ] pts on exenatide lost [13.58 vs
8.75

lb av] and had significantly greater mean reductions in HbA1C compared to
those taking placebo. They also had greater mean reductions in systolic BP.
The

rate of nausea was significantly higher with exenatide, but there were no
differences in withdrawal rates, adverse events or in hypoglycemia. "Our
findings

suggest a new paradigm for the treatment of T2," lead author said. This new
paradigm includes more medications like exenatide, "that do not exacerbate

insulin resistance and promote weight gain but do the opposite and help
diabetics lose weight and reduce insulin resistance,"  study was funded by
Lilly

USA,

 

32.%%  Erectile Dysfunction Drug Trial Meets Goals in Diabetic Patients
(Reuters) Jun 08 - Vivus Inc said a second late-stage study of its erectile
dysfunction

drug met the main goals of improving erectile function score across the two
doses that were studied in the trial.

[390 subjects] Commonly reported side effects included headache,
nasopharyngitis, flushing, sinus congestion, sinusitis and dyspepsia. There
were no drug-related

serious adverse events in the study.

 

33.%% Test Foods With Lower Glycemic Load (GL)Fail to Alter Metabolic  Risk
Markers in Overweight Individuals 6/4/10 — Diets fortified with foods low in

(GL) do not lower the risk for metabolic syndrome in high-risk individuals.
Together, a food's glycemic index (GI) and its total carbohydrates make up

its GL. The GI is a measurement of how much a carbohydrate-rich food will
elevate concentrations of blood glucose compared with white bread or a
glucose

solution. ..[ 9 men;6 women,] Glucose and lipids were not affected by the
test foods after weeks 1 and 5. Two limitations to the study stated by the
authors.

.. a result of a lack of precise information about the participants' overall
food intake, the researchers could not determine the GL or GI of the
participants'

complete diets, Am J Clin Nutr. Published online May 26, 2010.

 

Abbreviations:Fup-follow up; pt - patients;  DM - diabetes Mellitus; T1DM -
type 1 diabetes mellitus T2DM - type 2; DME - diabetic macular edema; GDM
gestational

diabetes;PDR - proliferative diabetic retinopathy;   FPG - fasting plasma
glucose; BP - blood pressure; CVD - cardio-vascular disease; MI -myocardial
infarction

or heart attack ;HTN - hypertension or high BP; OCT - optical coherence
tomography; VA - visual acuity  -ADA - Amer Diabetes Ass & ADA Professional
Resource

Online; JHA - Johns Hopkins Alerts ; MW Medscape Web MD; NIH - Nat
Institutes of Health;  MNTD- Medical News Today  NREndo;Nature Reviews
Endocrinology   

Definitions via online Medical dictionaries.  Disclaimer, I am a BSN RN but
not a diabetic or diabetic educator. Reports are excerpted unless otherwise

noted. This project is done as a courtesy to the blind/visually impaired and
diabetic communities. Dawn Wilcox BSN RN Coordinator The Health Library at

Vista Center; an affiliate of the Stanford Hospital Health Library.
contact above e-mail or 

thl at vistacenter.org     

           

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