[acb-diabetics] Byetta can be used as an anti-inflammatory

[Alice Ritchhart]

Pat
Please send me your e mail privately.
Thanks
Alice Ritchhart

At 12:50 PM 11/4/2011, you wrote:
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>Common Diabetes Drug Found to Have Powerful Anti-Inflamatory Effect
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>2-Nov-2011
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>November 2011 - Exenatide, a drug commonly prescribed to help 
>patients with type 2 diabetes improve blood sugar control, also has 
>a powerful and rapid anti-inflammatory effect, a University at 
>Buffalo study has shown.
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>The study of the drug, marketed under the trade name Byetta, was 
>published recently in the Journal of Clinical Endocrinology and Metabolism.
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>"Our most important finding was this rapid, anti-inflammatory 
>effect, which may lead to the inhibition of atherosclerosis, the 
>major cause of heart attacks, strokes and gangrene in diabetics," 
>says Paresh Dandona, MD, UB Distinguished Professor in the 
>Department of Medicine, UB School of Medicine and Biomedical 
>Sciences, and senior author.
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>It was especially noteworthy that this anti-inflammatory effect 
>occurred independently of weight loss over the 12-week study period, he adds.
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>"The fact that the drug caused this dramatic and comprehensive 
>anti-inflammatory effect independent of weight loss shows that it is 
>a primary action of the drug and is not dependent upon weight loss," 
>says Ajay Chaudhuri, MD, associate professor of medicine at UB and lead author.
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>He explains that, since obesity is an inflammatory state and adipose 
>tissue contributes to inflammation, weight loss on its own can lead 
>to an anti-inflammatory effect.
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>"Even more importantly, a short-lived anti-inflammatory effect was 
>observed within two hours following a single injection of 5 
>micrograms of the drug," Chaudhuri continues. "This coincides with 
>the peak concentration of the drug after the injection. Such a rapid 
>and dramatic effect is rare."
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>"Apart from corticosteroids, which are known anti-inflammatory 
>drugs, and insulin, no other drug demonstrates such a powerful and 
>rapid anti-inflammatory effect," adds Dandona.
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>As a result, he and his colleagues at UB plan to study how exenatide 
>might be used in acute inflammatory settings in the intensive care 
>unit or following heart attacks and strokes, where a rapid 
>anti-inflammatory effect is required and such drugs may be of potential use.
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>In addition to the anti-inflammatory effect, participants also 
>exhibited a drop in the measurement of average blood sugar levels 
>over three months, called hemoglobin A1C, from 8.6 percent to 7.4 percent.
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>The study involved 24 obese type 2 diabetics who were already on 
>insulin to control their glucose levels.
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>The current study was undertaken based on previous observations 
>published in 2007 by the UB researchers that exenatide indicated an 
>anti-inflammatory effect, reducing plasma C-reactive protein levels, 
>triglycerides and systolic blood pressure.
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>Co-authors with Chaudhuri and Dandona are Mehul Vora, MD, clinical 
>assistant instructor of medicine; Husam Ghanim, PhD, research 
>assistant professor of medicine; Sandeep Dhindsa, MD, and Antoine 
>Makdissi, MD, both assistant professors of medicine; and Chang Ling 
>Sia and Kelly Korzeniewski, research assistants in the UB Department 
>of Medicine, all of the Division of Endocrinology, Diabetes and 
>Metabolism of UB and Kaleida Health. The study was supported by a 
>grant from the Amylin Corporation and Eli-Lilly.
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>Source: University at Buffalo, The State University of New York
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