[acb-diabetics] The state of insulin injection

Fri Sep 16 13:20:47 EDT 2011

Thanks for all the info, Patricia.  It is good to read about advances in
diabetic research.

Julie Chinn

President, St. Charles County Council of the Blind

St. Charles, Missouri

  _____  

From: acb-diabetics-bounces at acb.org [mailto:acb-diabetics-bounces at acb.org]
On Behalf Of Patricia LaFrance-Wolf
Sent: Friday, September 16, 2011 12:03 PM
To: Acb-Diabetics at Acb. Org
Subject: [acb-diabetics] The state of insulin injection

The State of Insulin Injection

Diabetes Health Staff
Sep 11, 2011 

What's Being Researched Now

Oral Insulin <http://www.diabeteshealth.com/browse/medications/insulin/>
-With the demise of Pfizer Inc.'s inhaled insulin, Exubera, the next holy
grail for insulin delivery is oral insulin. The biggest problem in
developing oral insulin is finding a way to protect the delicate insulin
proteins from destruction by digestive system acids.

One current research approach is MonoSolRx Inc.'s edible film, which can be
stuck on the inside of a patient's cheek. The insulin-impregnated film
dissolves, passing insulin directly into the circulatory system. The New
Jersey-based company says that its film has worked well in monkeys and plans
to begin human trials later this year in Europe.

Emisphere Technologies, also based in New Jersey, signed a deal with Novo
Nordisk in late 2010 to develop an oral insulin. Neither company has stated
how long it expects development to take. Another company, Entrega in Boston,
is working on several orally taken drugs, including insulin.

Nanotechnology-Medical researchers at the University of California, San
Francisco, are working on developing a "nano-box," a tiny protective
container with insulin-producing beta cells inside. Microscopic holes in the
box are big enough to allow the cells to launch insulin into the
bloodstream, but small enough to block entry by the body's autoimmune system
agents. (For a video peek at the work being done on this by UCSF Professor
of Bioengineering Tejal Desai, go to
http://www.youtube.com/watch?v=rY_siujVJEg.)

Long-term Insulin-Insulin injections for type 2s
<http://www.diabeteshealth.com/browse/community/type-2-issues/>  could drop
to three per week, according to a study in the British medical journal The
Lancet. The study shows that type 2s who received once-daily or
thrice-weekly injections of degludec, a long-acting insulin, maintained
blood levels similar to those of patients receiving daily doses of insulin
glargine.

In the United States, about one in every three type 2 patients injects
insulin at least once daily. One problem that healthcare providers run into
when treating type 2s with insulin is getting them to adhere to an injection
schedule that requires daily injections.

Degludec is being developed by Novo Nordisk. If approved for US sale, it
would allow users to go 40 hours between injections-from 14 to 22 hours
longer than they can with current long-acting basal insulins. The drug also
can be mixed with other insulins. Novo is hoping to reach market by 2013.

Jet Injection-Although recent research shows that jet injection of insulin
can work twice as fast as pens in lowering glucose, the technology remains
cumbersome and requires a high level of patient commitment. So far, it has
not been widely accepted in the marketplace. If smaller, easier-to-use
devices can be developed, jet injection's quicker and needle-less delivery
could dramatically change consumer perceptions.

New on the Market

Smaller, Cost-saving Pen
<http://www.diabeteshealth.com/browse/products/pen-needles/>  Needle
Batches-UltiMed, which offers the only pen needles assembled in the United
States, has announced that it is now providing a 50-count universal-fit pen
needle.

Traditionally, pen needles are sold in batches of 100. After Walmart began
selling private-label pen needles in 50-count boxes, however, UltiMed
decided to enter the market with a matching offer.

The company says that as co-pays rise for many diabetes
<http://www.diabeteshealth.com/>  patients, the ability to buy pen needles
in smaller quantities could help them financially. The 50-count product also
opens the market to other suppliers and retailers who may want to follow
Walmart's lead.

Trends

Insulin Pens <http://www.diabeteshealth.com/browse/products/pens/> -Although
up to 90 percent of people with diabetes in some European countries use
insulin pens, US market penetration hovers around 20 percent. The higher
cost of the pens compared to the traditional vial-and-syringe
<http://www.diabeteshealth.com/browse/products/syringes/>  delivery system
is the most often cited reason for low acceptance. In their favor, however,
pens help users achieve better compliance and less waste of insulin because
the doses are premeasured.

  _____  

Categories: Degludec
<http://www.diabeteshealth.com/browse/medications/-degludec/> , jet
<http://www.diabeteshealth.com/browse/products/-jet-injection-of-insulin/>
injection of insulin, British
<http://www.diabeteshealth.com/browse/research/british-medical-journal-the-l
ancet/>  Medical Journal The Lancet, Exubera
<http://www.diabeteshealth.com/browse/medications/exubera/> , Inhaled
<http://www.diabeteshealth.com/browse/medications/inhaled-insulin/>
Insulin, insulin
<http://www.diabeteshealth.com/browse/medications/insulin-glargine/>
glargine, Insulin
<http://www.diabeteshealth.com/browse/medications/insulin-pens/>  Pens,
insulin <http://www.diabeteshealth.com/browse/research/insulin-proteins/>
proteins, long-acting
<http://www.diabeteshealth.com/browse/community/long-acting-insulin/>
insulin, Novo <http://www.diabeteshealth.com/browse/community/novo-nordisk/>
Nordisk, oral
<http://www.diabeteshealth.com/browse/medications/oral-insulin/>  insulin,
Pfizer <http://www.diabeteshealth.com/browse/products/pfizer/> , San
<http://www.diabeteshealth.com/browse/community/san-francisco/>  Francisco,
Type
<http://www.diabeteshealth.com/browse/complications-and-care/type-2-diabetes
/>  2 Diabetes, University
<http://www.diabeteshealth.com/browse/research/university-of-california/>
of California

  _____  

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