[acb-diabetics] finding the cure for neuropathic pain

[Patricia LaFrance-Wolf]

Scientists May Have Found Key to Neuropathic Pain


Diabetes Health Staff

May 26, 2012 

A compound found in excessive quantities in the glucose of people with
diabetes <http://www.diabeteshealth.com/>  may hold the key to successful
treatment of neuropathic pain, says an international team of researchers. 
The compound, methylglyoxal, attacks and modifies a protein, called Nav1.8,
in nerve endings.

This damage causes nerves to become much more sensitive to pain and
temperature extremes. The result in people with diabetes is neuropathy
<http://www.diabeteshealth.com/browse/complications-and-care/nerve-care-neur
opathy/> , nerve damage, and pain, especially in the limbs. An estimated 50
percent of people with diabetes suffer from this demoralizing and
debilitating condition.

Researchers, led by the University of Warwick in the UK, think that removing
methylglyoxal from diabetic <http://www.diabeteshealth.com/>  glucose could
be one way to counteract the development of neuropathy. They are currently
looking into an enzyme called Glo1, which causes methylglyoxal to undergo a
chemical change that cancels its ability to attack nerve endings.

Damage from high blood
<http://www.diabeteshealth.com/browse/monitoring/blood-sugar/>  sugar has
been a known factor for many years. But pinpointing this one specific effect
opens the door for an effective anti-pain therapy.

  _____  

Categories: Anti
<http://www.diabeteshealth.com/browse/complications-and-care/anti-pain/>
Pain, Compound <http://www.diabeteshealth.com/browse/research/compound/> ,
Diabetes <http://www.diabeteshealth.com/browse/community/diabetes/> ,
Diabetic <http://www.diabeteshealth.com/browse/health-care/diabetic/> ,
Enzyme <http://www.diabeteshealth.com/browse/research/enzyme/> , Glo1
<http://www.diabeteshealth.com/browse/research/glo1/> , Glucose
<http://www.diabeteshealth.com/browse/complications-and-care/glucose/> ,
High
<http://www.diabeteshealth.com/browse/complications-and-care/high-blood-suga
r/>  Blood Sugar, Limbs
<http://www.diabeteshealth.com/browse/complications-and-care/limbs/> ,
Methylglyoxa <http://www.diabeteshealth.com/browse/research/methylglyoxa/> ,


 

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