[acb-diabetics] Absence of Certain Proteins Causes Diabetes, and Rheumatoid Arthritis

[Veronica Elsea]

Wow, very interesting to me, as I have both type 1 diabetes and 
rheumatoid arthritis. I'd always heard that having one autoimune disease 
predisposes you to another, but never seen a decent explanation for such 
a connection. Interesting stuff.

Veronica


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On 9/16/2012 3:01 PM, Patricia LaFrance-Wolf wrote:
> *Absence of Certain Proteins Causes Diabetes, and Rheumatoid Arthritis*
>
> *The absence of related protein molecules, Puma and Bin, prompts immune
> cells to turn against human organs they are meant to protect and cause
> type 1 diabetes and rheumatoid arthritis....*
>
> Advertisement
>
> Daniel Gray and colleagues from the Walter and Eliza Hall Institute's
> Molecular Genetics of Cancer division and the University of Ballarat,
> have discovered that this pair of protein molecules work together to
> kill so-called 'self-reactive' immune cells that are programmed to
> attack the body's own organs.
>
> Autoimmune diseases, such as type-1 diabetes, rheumatoid arthritis,
> inflammatory bowel disease and multiple sclerosis, develop when immune
> cells launch an attack on the body's own cells, destroying important
> body organs or structures.
>
> Puma and Bim are so-called 'BH3-only' proteins that make cells die by a
> process called apoptosis or self death. Defects in apoptosis proteins
> have been linked to many human diseases, including cancer and
> neurodegenerative disorders, according to an Eliza Hall statement.
>
> Gray said one way the body protects itself against autoimmune disease is
> by forcing most self-reactive immune cells to die during their
> development. "If any self-reactive cells manage to reach maturity, the
> body normally has a second safeguard of switching these potentially
> dangerous cells into an inactive state, preventing them from causing
> autoimmune disease," he said.
>
> Gray is now collaborating with researchers who have identified human
> gene defects linked to the development of autoimmune conditions.
>
> "We now know that self-reactive cell death is an important protection
> against autoimmunity," Gray said. "The next stage of our work is to
> discover whether defects in the cell death process cooperate with other
> factors to cause human autoimmune disease."
>
> /Immunity Sept. 2012/
>
> *Related Articles*
>
>
>
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